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KMID : 0352720180420030356
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Journal of Ginseng Research
2018 Volume.42 No. 3 p.356 ~ p.360
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GBCK25, fermented ginseng, attenuates cardiac dysfunction in high fat diet-induced obese mice
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Sharmila Judith
Aravinthan Adithan
Shin Dong-Gue
Seo Jeong-Hun
Kim Bum-Seok
Kim Nam-Soo
Kang Chang-Won
Kim Jong-Hoon
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Abstract
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The fermentation of medicinal herbs facilitated by microbes is assumed to exert promising therapeutic efficacy on the absorption, bioavailability, and pharmacological effects by speeding up the making or conversion of active constituents into their metabolites. We examined the cardioprotective potential of fermented ginseng, GBCK25, against high-fat diet (HFD)-induced metabolic and functional illnesses as following the essential analysis such as electrocardiographic parameters, alterations of body and organ weights, and echocardiographic studies. The results exhibited that body weights were significantly reduced and the gain of different organ weights were partly eased by GBCK25 treatment. Echocardiography results proposed the amelioration of heart function through normalized levels of left ventricle systolic pressure, ejection fraction, and fractional shortening. These outcomes deliver straight confirmation that GBCK25 could be a potential nutraceutical source for the relief of HFD-induced obesity mediated cardiac dysfunctions.
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KEYWORD
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fermented ginseng, hemodynamics, high-fat diet, obesity, protection
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